In a freeze-drying process, one of the limiting factors in the duration of a cycle is the design of the
freeze dryer, specifically the choked flow between the chamber and condenser. In this study the
phenomenon of choked flow is explored, along with different factors that can significantly aid in
avoiding choked flow in aggressive recipes from the design phase. Finally, a specific project is analysed
where simulations of the flow in the freeze dryer helped in raising the maximum sublimation rate by
30% with design modifications.
Related news
Fulfilling Annex I in sterile drug production: when to use automatic loading and unloading systems for freeze dryers
Sterile drug production has always been a challenging task to perform in th...
New trends: Green Engineering, sustainability through a proper design
In today’s situation, sustainability is a more critical concept in engine...
Air flow smoke pattern testing: a new challenge in a subjective test in Annex 1 EU GMP
In the maintenance process of aseptic facilities, one of the tests of high importance is the ‘A...
Exploring sustainable cooling solutions for freeze dryers. A focus on natural gases
Mechanical refrigeration systems are an important factor against global cli...